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The design of experiments ( DOE , DOX , or experimental design ) is the design of any task that aims to describe or explain the variation of information under conditions that are hypothesized to reflect the variation. The term is generally associated with true experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments , in which natural conditions that influence the variation are selected for observation.

The agency is administered by the United States Secretary of Energy , and its headquarters are located in Southwest Washington, D.C. , on Independence Avenue in the James V. Forrestal Building , named for James Forrestal , as well as in Germantown , Maryland .